Speaker：Yiwen Zhang (张怡文) Aoyue Mao (茅傲岳) Lai Wei (魏来)

Abstract:

The homeostatic control of body temperature is essential for survival in mammals. When we get fever, we can sense the increase of body temperature by a cold feeling. That’s probably why people name getting “fever” also as catching “cold”. However, the temperature sensing and controlling mechanism was largely unknown. But the recent two years witnessed big progress in this field, as several labs published four important papers in molecular, cellular and circuit levels in attempt to illuminate body temperature homeostasis. Two of them discovered the important role of TRPM2 in temperature sensing for the first time, and two other papers revealed the warming sensitive neurons and circuits. While the picture is far from complete, the recent intensive high-level publications indicated that this field is getting to a very exciting stage.

Guest information:

1. Dr. Wei Shen (沈伟) (ShanghaiTech)

http://www.shanghaitech.edu.cn/faculty/slst/people/1036.html

2. Dr. Yang Jing (杨竞) (PKU)

http://mgv.pku.edu.cn/?co=posts&ac=faculty&catalog=enpiintro&pname=en_Jing_Yang

3. Zuying Chai (柴祖映) (PKU)

Graduate student of Dr. Zhuang Zhou (周专) (PKU)

http://www.imm.pku.edu.cn/kytd/rcdw/23691.htm

Recommend Literatures：

Review:

1. Morrison, S. F. (2016). Central control of body temperature. F1000Research, 5.

Link：https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870994/

Papers:

1. Tan, C. H., & McNaughton, P. A. (2016). The TRPM2 ion channel is required for sensitivity to warmth. Nature, 536(7617), 460-463.

Link: https://www.nature.com/articles/nature19074

2. Zhao, Z. D., Yang, W. Z., Gao, C., Fu, X., Zhang, W., Zhou, Q., ... & Xu, X. H. (2017). A hypothalamic circuit that controls body temperature. Proceedings of the National Academy of Sciences, 114(8), 2042-2047.

Link: http://www.pnas.org/content/114/8/2042.short