Speaker：Ke Bai (白珂) Yupu Wang (王玉璞) Zelin Wei (魏泽林)

Abstract:

The determination of final organ size is a highly coordinated and complex process that relies on the precise regulation of cell number and/or cell size. Perturbation of organ size control contributes to many human diseases, including hypertrophy, degenerative diseases, and cancer. Hippo and TOR are among the key signaling pathways involved in the regulation of organ size through their respective functions in the regulation of cell number and cell size. Besides these signaling pathways, cell-cell interaction is an unavoidable factor which is involved in organ size control. Some researches have pointed out cytoskeletal tension can inhibit hippo signaling pathway, therefore promote cell growth. Take them together, in this journal club, we would discuss the effect of signaling pathways and tension on organ size control.

Guest information:

1. Dr. Yan Song (PKU)

http://cls.pku.edu.cn:8080/index.php?m=content&c=index&a=show&catid=81&id=60

2. Dr. Jian Zhu (PKU)

http://cls.pku.edu.cn:8080/index.php?m=content&c=index&a=show&catid=81&id=58

Recommend Literatures：

Review:

1. Hariharan, I. K. (2017). Organ Size Control: Lessons from Drosophila. Developmental Cell, 34, 255-265.

Link：http://www.sciencedirect.com/science/article/pii/S1534580715004852?via%3Dihub

Papers:

1. Pan Y., Heemskerk I., Ibar C., Shraiman B. I., & Irvine K. D. (2016). Differential growth triggers mechanical feedback that elevates Hippo signaling. PNAS, 113(45), E6974-E6983.

Link: http://www.pnas.org/content/113/45/E6974.long

2. Liang J., Balachandra S., Ngo S., O’Brien L. E. (2017). Feedback regulation of steady-state epithelial turnover and organ size. Nature, 548, 588-591.

Link: https://www.nature.com/articles/nature23678