Speaker：Yige Zhao (赵依阁) Anqi Yu (于安琪) Liyuan Zhu (朱理源)

Abstract:

CRISPR-Cas9 is a powerful tool for genome editing. In 2015, a Chinese team from Sun Yat-sen University in Guangzhou reported editing the genomes of human embryos, which sheds light on the therapy of genetic disorders and generates a serious of ethical problems. There are two technical obstacles: off-target effects and mosaics generation. Recent advances minimize mosaics generation and largely increase the efficiency of embryo editing. Will the technical advance on embryo editing ultimately lead to “designer babies” in the first half of the 21st century? A brave new world awaits.

Guest information:

1. Dr. Shiyou Zhu (朱诗优) from Dr. Wensheng Wei (魏文胜)’s lab (PKU)

http://www.cls.edu.cn/PrincipalInvestigator/pi/index2727.shtml

2. Dr. Haoyi Wang (王皓毅) (CAS)

http://sourcedb.ioz.cas.cn/zw/zjrc/shengzhi/201402/t20140210_4031460.html

3. Dr. Yi Rao (饶毅) (PKU)

http://www.cls.edu.cn/PrincipalInvestigator/pi/index1579.shtml

Recommend Literatures：

Review:

1. Komor, Alexis C., Ahmed H. Badran, and David R. Liu. "CRISPR-based technologies for the manipulation of eukaryotic genomes." Cell 168.1-2 (2017): 20-36.

Link：http://www.sciencedirect.com/science/article/pii/S0092867416314659

Papers:

1.Liang, Puping, et al. "CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes." Protein & cell 6.5 (2015): 363-372.

Link: https://link.springer.com/article/10.1007/s13238-015-0153-5

2.Mitalipov, Shoukhrat. "Correction of a pathogenic gene mutation in human embryos." (2017).

Link: https://www.nature.com/articles/nature23305