Speaker：Jiali Duan (段佳丽) Kailong Wen (温凯隆) Liyang Liu (刘立洋) Yuxiang Huang (黄宇翔)

Abstract:

How axons repair themselves after injury is a fundamental question in neurobiology. With its conserved genome, relatively simple nervous system, and transparent body, C. elegans has recently emerged as a productivemodel to uncover the cellular mechanisms that regulate and execute axon regeneration. In this Journal Club, we discuss the strengths and weaknesses of the C. elegans model of regeneration. We hope to explore the technical advances that enable the use of C. elegans for in vivo regeneration studies, review findings in C. elegans that have contributed to our understanding of the regeneration response across species, discuss the potential of C. elegans research to provide insight into mechanisms that function in the injured mammalian nervous system, and present potential future directions of axon regeneration research using C. elegans.

Guest information:

1. Dr. Yishi Jin (UCSD)

http://biology.ucsd.edu/research/faculty/yijin

2. Dr. Song Yan (PKU)

http://cls.pku.edu.cn:8080/index.php?m=content&c=index&a=show&catid=81&id=60

3. Dr. Yang Jing (PKU)

http://mgv.pku.edu.cn/?co=posts&ac=faculty&catalog=enpiintro&pname=en_Jing_Yang

Recommend Literatures：

Review:

1. Byrne, A. B., & Hammarlund, M. (2017). Axon regeneration in C. elegans: Worming our way to mechanisms of axon regeneration. Experimental neurology, 287, 300-309.

Link：https://www.sciencedirect.com/science/article/pii/S0014488616302540

2. Bejjani, R. E., & Hammarlund, M. (2012). Neural regeneration in Caenorhabditis elegans. Annual review of genetics, 46, 499-513.

Link: http://www.annualreviews.org/doi/abs/10.1146/annurev-genet-110711-155550

Papers:

1. Yan, D., Wu, Z., Chisholm, A. D., & Jin, Y. (2009). The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. Cell, 138(5), 1005-1018.

Link: https://linkinghub.elsevier.com/retrieve/pii/S0092-8674(09)00723-5

2. Byrne, A. B., Walradt, T., Gardner, K. E., Hubbert, A., Reinke, V., & Hammarlund, M. (2014). Insulin/IGF1 signaling inhibits age-dependent axon regeneration. Neuron, 81(3), 561-573.

Link: http://www.cell.com/neuron/fulltext/S0896-6273(13)01087-8?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627313010878%3Fshowall%3Dtrue