Speaker：Wei Lu (卢巍) Lan Luo (罗兰) Yupu Wang (王玉璞)

Abstract:

The idea that memory is stored in the brain as physical alterations goes back at least as far as Plato, but further conceptualization of this idea had to wait until the 20th century when two guiding theories were presented: the “engram theory” of Richard Semon and Donald Hebb’s “synaptic plasticity theory.” In this Journal Club, we will discuss these two theories. Furthermore, with the understanding of memory mechanism, we can manipulate the recall and context of the memory. This memory transplantation and manipulation methods may shed lights in the future treatments of psychological diseases like Alzheimer’s disease and depression.

Guest information:

Dr. Jiongjiong Yang (PKU)

https://www.psy.pku.edu.cn/c/faculty/yang-jiong-jiong.html

Recommend Literatures：

Review:

1.  Tonegawa, S., Liu, X., Ramirez, S. & Redondo, R. Memory Engram Cells Have Come of Age. Neuron 87, 918–931 (2015).

Link: http://www.sciencedirect.com/science/article/pii/S0896627315006777?via%3Dihub

Papers:

1. Ramirez, S. et al. Creating a false memory in the hippocampus. Science 341, 387–91 (2013).

Link: http://science.sciencemag.org/content/341/6144/387.long

2. Nabavi, S. et al. Engineering a memory with LTD and LTP. Nature 511, 348–352 (2014).

Link: https://www.nature.com/articles/nature13294