Speaker：Yuchun Wang (王雨纯) Zelin Wei (魏泽林)

Title: Motor neuron diversity in C.elegans

Abstract:

Movement is one of the critical abilities for animals to survive. In human being, there are around 600 subtypes of muscles and around 600 subtypes of motor neurons to control the locomotion. One of the fundamental question in developmental neurobiology is that how the diversity of motor neuron is generated and maintained during life. To address this question, researchers use C. elegans as a model animal because of its system simplicity and evolutionary conservation. It’s reported that UNC-3, an evolutionary conserved transcription factor, regulates both the shared and the type-specific molecular features of different motor neurons. UNC-3 collaborates with different type-specific repressors to achieve the motor neuron diversity. Further research would constitute a general principle for motor neuron diversity across species.

Guest information:

1. Dr. Song Yan (PKU)

http://cls.pku.edu.cn:8080/index.php?m=content&c=index&a=show&catid=81&id=60

2. Dr. Jian Zhu (PKU)

http://cls.pku.edu.cn:8080/index.php?m=content&c=index&a=show&catid=81&id=58

Recommend Literatures：

Review:

1. Kanning, Kevin C., Artem Kaplan, and Christopher E. Henderson. "Motor neuron diversity in development and disease." Annual review of neuroscience33 (2010): 409-440.

Link: http://www.annualreviews.org/doi/pdf/10.1146/annurev.neuro.051508.135722

Papers:

1. Kratsios, Paschalis, et al. "Coordinated regulation of cholinergic motor neuron traits through a conserved terminal selector gene." Nature neuroscience 15.2 (2012): 205-214.

Link: https://www.nature.com/articles/nn.2989.pdf

2. Kerk, Sze Yen, et al. "Diversification of C. elegans Motor Neuron Identity via Selective Effector Gene Repression." Neuron 93.1 (2017): 80-98.

Link:https://ac.els-cdn.com/S0896627316309047/1-s2.0-S0896627316309047-main.pdf?_tid=c10df392-d9b0-11e7-8237-0000aab0f6c&acdnat=1512474063_9e31d37280da3b578545c4d5046d1ac1